On March 17th, just as many countries were taking draconian measures to contain the SARS-COV-2 pandemic, the Greek-American meta-researcher and epidemiologist John Ioannidis, whom I often quote in my posts proclaimed a “fiasco in the making‘! With strong language and a few ad hoc estimations of COVID fatality rates he warned that based on poor data or no evidence at all politicians might inflict incalculable damage on society, possibly much worse than what a virus, putatatively as dangerous as influenza, could cause. As one of the most highly cited researchers in the world and a vocal critic of quality problems in biomedicine, his COVID related interviews, opinion pieces and articles since then have received a great deal of attention, in the scientific community, in the lay press, and especially among his worldwide fan base. Continue reading
Research using animals is a sensitive issue. Anyone who does animal experiments, like myself, is reluctant to talk about it, at least outside our natural habitat, the laboratory or scientific conventions. Institutions where animal experiments are carried out are also quite shy about the topic. Recently, the Max Planck Society left Nikos Logothetis (MPI Tübingen) standing in the rain when he was targeted by a media campaign. Now he and some of his laboratory staff are off to Shanghai… The websites of prominent research institutes feature all kinds of colorful illustrations showing immunohistochemistry slides, doctors and students in white coats with pipettes in their hands, sitting at computers or their microscopes. But rats or mice are conspicuously missing! They proudly display their research activities, and enthusiastically advertise (future) research breakthroughs towards completely new and effective therapies. But no reference is made to animal experiments on campus!
Meat consumption is bad for your health. It gives you cancer, heart attacks, stroke, you name it. Says nutrition science. And they must know. After all, it’s a science. Is it, really?
A few years ago, Jonathan Schoenfeld and John Ioannidis took a standard cookbook and randomly selected 50 frequently occurring ingredients (sugar, coffee, salt, etc.). They then carried out a systematic literature search, asking whether there were epidemiologicial studies that had investigated the cancer risk of these ingredients. And they found what they were looking for. For 80% of the ingredients at least one study existed, for many even several. Of 264 of these studies, 103 found that the ingredient investigated increased the risk of cancer, while 88 reduced the risk! So after all Joe Jackson was right: ‘Everything gives you cancer’! But wait a minute: Milk? Veal? Orange juice? Continue reading
Spektrum der Wissenschaft
AUS FORSCHUNG WIRD GESUNDHEIT
Wie gut ist die biomedizinische Forschung?
Heute stellen wir die Frage: Wie gut ist die biomedizinische Forschung? Stimmt es, was John Ioannidis von der amerikanischen Universität Stanford behauptet hat, dass die Hälfte aller wissenschaftlichen Artikel falsch sind? Beantworten kann mir diese Frage Professor Ulrich Dirnagl. Er leitet am Berlin Institute of Health das BIH Quest Center, das die Qualität und Ethik in der Wissenschaft erforscht. Er hat John Ioannidis ans BIH eingeladen, um als Einstein BIH Visiting Fellow mit ihm zusammen zu arbeiten.
Dichtung und Wahrheit in der Forschung
Ulrich Dirnagl ist Professor für Neurologie an der Charité – und “Wissenschaftsnarr”, als der er regelmäßig eine Kolumne im “Laborjournal” schreibt. Mit Thomas Prinzler spricht er über Qualität und Ethik in der biomedizinischen Forschung. Denn zu oft würden Ergebnisse weggelassen oder auch gefälscht.
Wo Professor Zufall regiert
Zu wenige Versuchspersonen, unsauber geplante Experimente, keine Replikation der Untersuchung: viele biomedizinische Studien haben Schwächen. So große, dass man stattdessen genauso gut eine Münze werfen könnte, meint der Neurologe Ulrich Dirnagl.
Podcast Spektrum – Wirkstoffradio (André Lampe und Bernd Rupp)
Podcast Kritisches Denken (Philip Barth, Andreas Blessing)
Episode 25 – Qualität in der Forschung
Im ersten Teil des Gesprächs mit Prof. Ulrich Dirnagl von der Charité Berlin sprechen wir über strukturelle Probleme in der Forschungslandschaft, die Reproduzierbarkeitskrise und den p-Wert. Details zur Episode
Podcast Kritisches Denken (Philip Barth, Andreas Blessing)
Episode 26 – Mikrobiomforschung und andere Hype-Zyklen
In Teil 2 des Gesprächs mit Prof. Ulrich Dirnagl unterhalten wir uns über die Mikrobiomforschung und wie Hype-Zyklen in der Wissenschaft verlaufen.
Podcast Gesundheit Macht Politik
Ulrich Dirnagl | Forschung: This is an intergalactic emergency
And here’s a video cast from the European Academy of Neurology
You got to see this youtube video! Hectically cut sequences of busy young scientists in high-tech laboratories wearing lab coats, nerdy looking guys are soldering electronic circuits and stare into oscilloscopes, we are taken on a roller coaster ride through an animated brain chockful of tangled nerve cells. And in between all this, on stage at the California Academy of Sciences, car and rocket manufacturer Elon Musk announces his latest vision in a messianic pose: The symbiosis of the human brain with artificial intelligence (AI)! This time his plan to save mankind does not involve mass evacuation to Mars, but will be realized by a revolutionary Brain Machine Interface (BMI), designed and manufactured by his company Neuralink. You may have guessed it, this has caused a tremendous media hype all over the world. The verdict in the press and on the net was: “Musk at his best, a bit over the edge, but if HE announces a breakthrough like that there must be something to it”. The more cautious asked: “But couldn’t this be dangerous for mankind? Do we need a new ethic for stuff like this?” Continue reading
Recently in a train station book shop I stood gaping in astonishment in front of a thematically highly specialized book display. It was the bowels-brain table. The books piled up on it promised enlightenment about how the bowel and in particular its contents influence us – yes – how, they verily steer our emotions. A selection of book titles: “Shit-Wise – How a Healthy Intestinal Flora Keeps us fit”; “Bowels heal brain heal body”; “Happiness begins in the bowels”, or “The second brain – How the bowels influence our mood, our decisions and our feeling of wellbeing”. Newspapers, magazines and the internet can also tell us this. The wrong bowel bacteria make us depressive – but the right ones make us happy … which is why yogurt helps against depression. Continue reading
U.S. economist Robin Hanson posed this question in the title of an article published in 1995. In it he suggested replacing the classic review process with a market-based alternative. Instead of peer review, bets could decide which projects will be supported or which scientific questions prioritized. In these so-called “prediction” markets, individuals stake “bets” on a particular result or outcome. The more people trade on the marketplace, the more precise will be the prediction of outcome, based as it is on the aggregate information of the participants. The prediction market thus serves the intellectual swarms. We know that from sport bets and election prognoses. But in science? Sounds totally crazy, but it isn’t. Just now it is making its entry into various branches of science. How does it function, and what does it have going for it? Continue reading