Sloppyness and effect size correlate linearly in clinical stem cell trials

ImageDiscrepancies in the publication of clinical trials of bone marrow stem cell therapy in cardiology scale linearly with effect size! This is the shocking but not so surprising result of a study in BMJ that found over 600 discrepancies in 133 reports from 49 trials. Trials without discrepancies (only 5!) reported neutral results (i.e. no effect of therapy on enhancement of ejection fraction). The most spectacular treatment effects were found in those trials with the highest number of discrepancies (30 and more).

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s