Einsichten eines Wissenschaftsnarren

narrLeseempfehlungen zur Laborjournal Kolumne:

(Und hier geht es zum Archiv aller Artikel)



Einsichten eines Wissenschaftsnarren (32):

Chambers, C. D., & Tzavella, L. (2020, February 10). Registered Reports: Past, Present and Future https://osf.io/preprints/metaarxiv/43298/

Editorial. Nature will publish peer review reports as a trial. Nature 578, 8 (2020) https://www.nature.com/articles/d41586-020-00309-9

Elsevier/Sense about Science. Quality, trust & peer review: researchers’ perspectives 10 years on. Sept 2019 https://senseaboutscience.org/wp-content/uploads/2019/09/Quality-trust-peer-review.pdf

Glonti, K., Cauchi, D., Cobo, E. et al. A scoping review on the roles and tasks of peer reviewers in the manuscript review process in biomedical journals. BMC Med 17, 118 (2019). https://doi.org/10.1186/s12916-019-1347-0

Heesen R, Bright LK. Is Peer Review a Good Idea?, The British Journal for the Philosophy of Science, axz029, https://academic.oup.com/bjps/advance-article/doi/10.1093/bjps/axz029/5526887

Jump P. Slay peer review ‘sacred cow’, says former BMJ chief. Times Higher Education 21.4.2020 https://www.timeshighereducation.com/news/slay-peer-review-sacred-cow-says-former-bmj-chief/2019812.article#

Mazer B. To Maintain Trust in Science, Lose the Peer Review. Medscape 19.2.2019 https://www.medscape.com/viewarticle/908647?src=WNL_infoc_190223_MSCPEDIT_Ward&uac=124874SX&impID=1892056&faf=1

Peterson GI. Postpublication peer review: A crucial tool. Science  16 Mar 2018:Vol. 359, Issue 6381, pp. 1225-1226 https://science.sciencemag.org/content/359/6381/1225.2

Smith RJ. Peer review: a flawed process at the heart of science and journal. J R Soc Med. 2006 Apr; 99(4): 178–182. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420798/#!po=79.1667

Vazire S. Peer-Reviewed Scientific Journals Don’t Really Do Their Job. WIRED 26.6.2020 https://www.wired.com/story/peer-reviewed-scientific-journals-dont-really-do-their-job/


Einsichten eines Wissenschaftsnarren (31):

Empfehlungen zur Förderung translationaler Forschung in der Universitätsmedizin. Stellungnahme der Arbeitsgruppe „Translation“ der Ständigen Senatskommission für Grundsatzfragen in der Klinischen Forschung der Deutschen Forschungsgemeinschaft. (2019) https://www.dfg.de/download/pdf/dfg_im_profil/reden_stellungnahmen/2019/190919_stellungnahme_empfehlung_ag_translation.pdf

Dirnagl U. Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It? Stroke. 2016 Aug;47(8):2148-53. https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.116.013244

Djulbegovic B, Kumar A, Glasziou P, Miladinovic B, Chalmers I. Medical research: Trial unpredictability yields predictable therapy gains. Nature. 2013 Aug 22;500(7463):395-6. https://www.nature.com/articles/500395a.

Wieschowski S, Riedel N, Wollmann K, Kahrass H, Müller-Ohlraun S, Schürmann C, Kelley S, Kszuk U, Siegerink B, Dirnagl U, Meerpohl J, Strech D. Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete. J Clin Epidemiol. 2019 Nov;115:37-45. https://www.sciencedirect.com/science/article/pii/S0895435618310631

London AJ, Kimmelman J. Why clinical translation cannot succeed without failure. Elife. 2015 Nov 24;4:e12844. https://elifesciences.org/articles/12844

Strech D, Dirnagl U3Rs missing: animal research without scientific value is unethical. BMJ Open Science 2019;3:bmjos-2018-000048. https://openscience.bmj.com/content/3/1/e000048


Einsichten eines Wissenschaftsnarren (30):

Aleszu Bajak and Jeff Howe. A Study Said Covid Wasn’t That Deadly. The Right Seized It. New York Times May 14, 2020. https://www.nytimes.com/2020/05/14/opinion/coronavirus-research-misinformation.html?action=click&module=Opinion&pgtype=Homepage

Stephanie M Lee. JetBlue’s Founder Helped Fund A Stanford Study That Said The Coronavirus Wasn’t That Deadly. BuzzFeed News May 15, 2020. https://www.buzzfeednews.com/article/stephaniemlee/stanford-coronavirus-neeleman-ioannidis-whistleblower

John P.A. Ioannidis A fiasco in the making. Statnews 2020.  https://www.statnews.com/2020/03/17/a-fiasco-in-the-making-as-the-coronavirus-pandemic-takes-hold-we-are-making-decisions-without-reliable-data/

John P. A. Ioannidis, Cathrine Axfors, Despina G. Contopoulos-Ioannidis. Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters. medRxiv 2020.04.05.20054361;  https://www.medrxiv.org/content/10.1101/2020.04.05.20054361v1

Eran Bendavid, Bianca Mulaney, Neeraj Sood, Soleil Shah, Emilia Ling, Rebecca Bromley-Dulfano, Cara Lai, Zoe Weissberg, Rodrigo Saavedra, James Tedrow, Dona Tversky, Andrew Bogan, Thomas Kupiec, Daniel Eichner, Ribhav Gupta, John Ioannidis, Jay Bhattacharya. COVID-19 Antibody Seroprevalence in Santa Clara County, California medRxiv 2020.04.14.20062463; https://www.medrxiv.org/content/10.1101/2020.04.14.20062463v1

John P.A. Ioannidis. Why Most Published Research Findings Are False. PLoS Med  2005. 2(8): e124. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124

Andrew Gelman. Concerns with that Stanford study of coronavirus prevalence. April 19, 2020. https://statmodeling.stat.columbia.edu/2020/04/19/fatal-flaws-in-stanford-study-of-coronavirus-prevalence/

Vinay Prasad and Jeffrey S. Fliers. Scientists who express different views on Covid-19 should be heard, not demonized last accessed APRIL 27, 2020 https://www.statnews.com/2020/04/27/hear-scientists-different-views-covid-19-dont-attack-them/

Freddie Sayers. Which epidemiologist do you believe? The debate about lockdown is not a contest between good and evil. Last accessed 29.4.2020 https://unherd.com/2020/04/which-epidemiologist-do-you-believe/

Amit Sud, Michael E. Jones, John Broggio, Chey Loveday, Bethany Torr, Alice Garrett, David L. Nicol, Shaman Jhanji, Stephen A. Boyce, Phillip Ward, Jonathan M. Handy, Nadia Yousaf, James Larkin, Yae-Eun Suh, Stephen Scott, Paul D.P. Pharoah, Charles Swanton, Christopher Abbosh, Mattew Williams, Georgios Lyratzopoulos, Richard Houlston, Clare Turnbull. Collateral damage: the impact on cancer outcomes of the COVID-19 pandemic. medRxiv 2020.04.21.20073833; doi: https://doi.org/10.1101/2020.04.21.20073833

Bernhard Metzler, Peter Siostrzonek, Ronald K Binder, Axel Bauer, Sebastian Johannes Reinstadler, Decline of acute coronary syndrome admissions in Austria since the outbreak of COVID-19: the pandemic response causes cardiac collateral damage, European Heart Journal, , ehaa314, https://doi.org/10.1093/eurheartj/ehaa314

Dominik Andreas Moser, Jennifer Glaus, Sophia Frangou, Daniel Scott Schechter. Years of life lost due to the psychosocial consequences of COVID19 mitigation strategies based on Swiss data. medRxiv 2020.04.17.20069716; doi: https://doi.org/10.1101/2020.04.17.20069716

Kieran Docherty, Jawad Butt, Rudolf de Boer, Pooja Dewan, Lars Koeber, Aldo Maggioni, John McMurray, Scott Solomon, Pardeep Singh Jhund. Deaths from Covid-19: Who are the forgotten victims? medRxiv 2020.04.21.20073114; doi: https://doi.org/10.1101/2020.04.21.20073114

New York Times. U.S. Coronavirus Death Toll Is Far Higher Than Reported, C.D.C. Data Suggests. Last accessed 29.4.2020 https://www.nytimes.com/interactive/2020/04/28/us/coronavirus-death-toll-total.html?campaign_id=168&emc=edit_NN_p_20200429&instance_id=18058&nl=morning-briefing&regi_id=80080394&section=topNews&segment_id=26195&te=1&user_id=4dd821e626236c0a675dcf47e4b900bf

Alex London, Jonathan Kimmelman. Against pandemic research exceptionalism. Science. 2020 Apr 23. pii: eabc1731. https://science.sciencemag.org/content/early/2020/04/22/science.abc1731.long


Einsichten eines Wissenschaftsnarren (29):

Henley J. Coronavirus causing some anti-vaxxers to waver, experts say. The Guardian April 21, 2020 https://www.theguardian.com/world/2020/apr/21/anti-vaccination-community-divided-how-respond-to-coronavirus-pandemic?CMP=Share_iOSApp_Other

Bobrov E. Open Data can be advanced by the COVID-19 pandemic, but will still require a comprehensive approach. Elephant in the lab (blog) 30 March 2020, doi:10.5281/zenodo.3732948

Kubota T. Stanford researchers discuss the benefits – and perils – of science without peer review . Stanford News, April 6 2020. https://news.stanford.edu/2020/04/06/open-science-era-covid-19/

Schmidt M, Fecher B, Kobsdsa C, Koch E. Open Access in Near Time. Elephant in the lab (blog) 1 April 2020 https://elephantinthelab.org/open-access-near-time/

Apuzzo M, Kirkpatrick DD. Covid-19 Changed How the World Does Science, Together. New York Times, 4.4.2020 https://www.nytimes.com/2020/04/01/world/europe/coronavirus-science-research-cooperation.html

Lenzer J. Covid-19: US gives emergency approval to hydroxychloroquine despite lack of evidence. BMJ 2020;369:m1335 doi: 10.1136/bmj.m1335 (Published 1 April 2020)

Ritchie SA. Don’t trust the psychologists on coronavirus. Many of the responses to Covid-19 come from a deeply-flawed discipline. UnHerd (blog) 31 March 2020 https://unherd.com/2020/03/dont-trust-the-psychologists-on-coronavirus/

Ioannidis, J.P.A. (2020), Coronavirus disease 2019: The harms of exaggerated information and non‐evidence‐based measures. Eur J Clin Invest, 50: e13222 https://onlinelibrary.wiley.com/doi/full/10.1111/eci.13222

London AJ, Kimmelman J. Against pandemic research exceptionalism Science  23 Apr 2020: eabc1731 https://science.sciencemag.org/content/early/2020/04/22/science.abc1731

Majumder MS, Mandl KD. Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibilityLancet Glob Health 2020 Published Online March 24, 2020 https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30113-3/fulltext

neuromatch. A free webbased unconference in Computational Neuroscience. https://neuromatch.io/

COVID-evidence: a living database of trials on interventions for COVID-19. https://osf.io/gehfx/

COVID-19: A “Living” Evidence summary https://mfr.osf.io/render?url=https://osf.io/s7hpm/?direct%26mode=render%26action=download%26mode=render


Einsichten eines Wissenschaftsnarren (28):

A longer, English version of this article has appeared in :

Dirnagl U. Pre-registration of exploratory research: Learning from the golden age of discovery.  PLoS Biol 2020 18(3): e3000690


Heesen, R and Bright, LK (2018) Is Peer Review a Good Idea? British Journal for the Philosophy of Science. http://philsci-archive.pitt.edu/15040/

Brembs B. What should a modern scientific infrastructure look like?  http://bjoern.brembs.net/2015/04/what-should-a-modern-scientific-infrastructure-look-like/

Preprint info center – ASAPbio. https://asapbio.org/preprint-info

Chambers C. What’s next for Registered Reports? Nature. NLM (Medline); 2019. pp. 187–189. doi:10.1038/d41586-019-02674-6

Kimmelman J, Mogil JS, Dirnagl U. Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation. Jones DR, editor. PLoS Biol. 2014;12: e1001863. doi:10.1371/journal.pbio.1001863

Chambers C, Tzavella L. Registered Reports: Past, Present and Future. doi:10.31222/OSF.IO/43298

Schapira M, Harding RJ. Open laboratory notebooks: good for science, good for society, good for scientists. F1000Research. 2019;8: 87. doi:10.12688/f1000research.17710.2


Einsichten eines Wissenschaftsnarren (27):

Wehr M. Flucht vor der Scheinmoral. FAZ 17.1.2020 https://edition.faz.net/faz-edition/feuilleton/2020-01-17/15a47d095b3c2d91081a42b04164d026/?GEPC=s5

Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.  Nature. 2020 Jan 22. doi: 10.1038/s41586-020-1935-3

Baier T. Vor Stress ergraut. Süddeutsche Zeitung 23.1.2020 sueddeutsche.de/wissen/graue-haare-stress-1.4767023?reduced=true

Sheikh K. Stress Really Does Make Hair Go Gray FasterStress Really Does Make Hair Go Gray Faster New York Times 22.1.2020 https://www.nytimes.com/2020/01/22/science/gray-hair-stress.html

BBC News. Scientists discover ‘why stress turns hair white’ BBC 22.1.2020 https://www.bbc.com/news/health-51208972

Loss SR, Will T, Marra PP. The impact of free-ranging domestic cats on wildlife of the United States. Nat Commun. 2013;4:1396. https://www.nature.com/articles/ncomms2380

Wieschowski S, Biernot S, Deutsch S, Glage S, Bleich A, Tolba R, Strech D. Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres. PLoS One. 2019 Nov 26;14(11):e0223758. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223758

Strech D, Dirnagl U. 3Rs missing: animal research without scientific value is unethical. BMJ Open Science 2019;3:e000035. http://dx.doi.org/10.1136/bmjos-2018-000048


Einsichten eines Wissenschaftsnarren (26):

GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1923-1994. doi: 10.1016/S0140-6736(18)32225-6. Epub 2018 Nov 8.

MEDIZIN DER ZUKUNFT. Gene als Arznei – Neue Therapien revolutionieren die Medizin. Handelsblatt 23.7.2019 https://www.handelsblatt.com/unternehmen/industrie/medizin-der-zukunft-gene-als-arznei-neue-therapien-revolutionieren-die-medizin-/24686372.html?ticket=ST-1896810-FvJBe7kNtVsAnaOCBUfc-ap2

DIGITALISIERUNG UND GESUNDHEIT Die Medizin der Zukunft – Wie uns KI vor Krebs und Herzinfarkt schützt. Handelsblatt 1.2.2019 https://www.handelsblatt.com/technik/medizin/digitalisierung-und-gesundheit-die-medizin-der-zukunft-wie-uns-ki-vor-krebs-und-herzinfarkt-schuetzt/23919382.html


Vermeidbare Sterbefälle im Jahr 2013. eurostat Pressemitteilung 101/2016 – 24. Mai 2016 http://bit.ly/2tcyx77

Einsichten eines Wissenschaftsnarren (25):

Joe Jackson. Everything gives you cancer. On the LP: Night and Day 1982  https://www.youtube.com/watch?v=EM2MGN_w4sU

Schoenfeld JD, Ioannidis JP. Is everything we eat associated with cancer? A systematic cookbook review. Am J Clin Nutr. 2013 Jan;97(1):127-34. doi: 10.3945/ajcn.112.047142. Epub 2012 Nov 28. https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.047142

Resnick B and Belluz J. A top Cornell food researcher has had 15 studies retracted. That’s a lot. Brian Wansink is a cautionary tale in bad incentives in science. https://www.vox.com/science-and-health/2018/9/19/17879102/brian-wansink-cornell-food-brand-lab-retractions-jama

Boytchev B. Ist der Konsum von Fleisch nun ungesund oder nicht? Die Studien widersprechen sich. Anhänger beider Auslegungen streiten vehement. Was stimmt wirklich? Neue Züricher Zeitung am Sonntag 12.10.2019 https://nzzas.nzz.ch/wissen/rotes-fleisch-krebserregend-oder-nicht-ld.1514819

Estruch R, Ros E, Salas-Salvadó J, etal. PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet [retracted]. N Engl J Med 2013;368:1279-90. 10.1056/NEJMoa1200303 23432189 https://www.nejm.org/doi/full/10.1056/nejmoa1200303

Zeraatkar D, Johnston BC, Bartoszko J, Cheung K, Bala MM, Valli C, Rabassa M, Sit D, Milio K, Sadeghirad B, Agarwal A, Zea AM, Lee Y, Han MA, Vernooij RWM, Alonso-Coello P, Guyatt GH, El Dib R. Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials. Ann Intern Med. 2019 Oct 1. doi: 10.7326/M19-0622. [Epub ahead of print] https://www.annals.org/aim/fullarticle/doi/10.7326/M19-0622

Valli C, Rabassa M, Johnston BC, Kuijpers R, Prokop-Dorner A, Zajac J, Storman D, Storman M, Bala MM, Solà I, Zeraatkar D, Han MA, Vernooij RWM, Guyatt GH, Alonso-Coello P; NutriRECS Working Group. Health-Related Values and Preferences Regarding Meat Consumption: A Mixed-Methods Systematic Review. Ann Intern Med. 2019 Oct 1. doi: 10.7326/M19-1326. [Epub ahead of print] https://annals.org/aim/fullarticle/2752323/health-related-values-preferences-regarding-meat-consumption-mixed-methods-systematic

Vernooij RWM, Zeraatkar D, Han MA, El Dib R, Zworth M, Milio K, Sit D, Lee Y, Gomaa H, Valli C, Swierz MJ, Chang Y, Hanna SE, Brauer PM, Sievenpiper J, de Souza R, Alonso-Coello P, Bala MM, Guyatt GH, Johnston BC. Patterns of Red and Processed Meat Consumption and Risk for Cardiometabolic and Cancer Outcomes: A Systematic Review and Meta-analysis of Cohort Studies. Ann Intern Med. 2019 Oct 1. doi: 10.7326/M19-1583. [Epub ahead of print] https://annals.org/aim/fullarticle/2752327/patterns-red-processed-meat-consumption-risk-cardiometabolic-cancer-outcomes-systematic

Kolata G. Eat Less Red Meat, Scientists Said. Now Some Believe That Was Bad Advice.New York Times, 30.9.2019 https://www.nytimes.com/2019/09/30/health/red-meat-heart-cancer.html

Schwingshackl L, Schwedhelm C, Hoffmann G, et al. et al. Food groups and risk of all-cause mortality:a systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2017;105(6): 1462-1473.

Poole R, Kennedy OJ, Roderick P, et al. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024.

Wightman E. The ‘French paradox’ turned out to be an illusion, but it led to some interesting research. The Conversation. 2017 https://theconversation.com/the-french-paradox-turned-out-to-be-an-illusion-but-it-led-to-some-interesting-research-78196

Berres I. Moderater Alkoholkonsum: Die Mär vom gesunden Gläschen. Spiegel Online https://www.spiegel.de/gesundheit/diagnose/alkohol-und-gesundheit-die-maer-vom-gesunden-glas-rotwein-a-1017662.html

Even one drink a day increases stroke risk, study finds. BBC News 2019 https://www.bbc.com/news/health-47817650

Millwood IY, Walters RG, Mei XW, Guo Y, Yang L, Bian Z, Bennett DA, Chen Y, Dong C, Hu R, Zhou G, Yu B, Jia W, Parish S, Clarke R, Davey Smith G, Collins R, Holmes MV, Li L, Peto R, Chen Z; China Kadoorie Biobank Collaborative Group. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. Lancet. 2019 May 4;393(10183):1831-1842. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31772-0/fulltext

Knott CS, Coombs N, Stamatakis E, Biddulph JP. All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts.  BMJ. 2015 Feb 10;350:h384. https://www.bmj.com/content/350/bmj.h384.long

Gesundheit in Deutschland. Robert Koch Institut 2015 https://www.rki.de/DE/Content/Gesundheitsmonitoring/Gesundheitsberichterstattung/GesInDtld/GesInDtld_node.html

A ride along Chicago’s red line. The Economist Oct 10, 2019 https://www.economist.com/united-states/2019/10/10/a-ride-along-chicagos-red-line

Ioannidis JPA, Trepanowski JF. Disclosures in Nutrition Research: Why It Is Different. JAMA. 2018 Feb 13;319(6):547-548. https://jamanetwork.com/journals/jama/article-abstract/2666008

Ioannidis JPA. The Challenge of Reforming Nutritional Epidemiologic Research. JAMA. 2018 Sep 11;320(10):969-970. doi: 10.1001/jama.2018.11025. https://jamanetwork.com/journals/jama/article-abstract/2698337


Einsichten eines Wissenschaftsnarren (24):

Becker, M. Wissenschaft im Gegenwind. https://www.heise.de/tp/features/Wissenschaft-im-Gegenwind-4517042.html

Becker M. Wer hat uns die Fakten geklaut. https://www.heise.de/tp/features/Wer-hat-uns-die-Fakten-geklaut-4532552.html

Mertonian Norms (Wikipedia) https://en.wikipedia.org/wiki/Mertonian_norms


Einsichten eines Wissenschaftsnarren (23):

Mein Editorial zum Thema:

Dirnagl U. The p value wars (again). Eur J Nucl Med Mol Imaging. 2019 Aug 3. doi: 10.1007/s00259-019-04467-5. [Epub ahead of print] https://link.springer.com/article/10.1007%2Fs00259-019-04467-5


Weg mit dem p-Wert:

Anjana, A. Scientists strike back against statistical tyranny | Financial Times. Financial Times (2019). https://www.ft.com/content/36f9374c-5075-11e9-8f44-fe4a86c48b33

Amrhein, V., Greenland, S. & McShane, B. Scientists rise up against statistical significance. Nature 567, 305–307 (2019). https://www.nature.com/articles/d41586-019-00857-9

Benjamin, D. J. et al. Redefine statistical significance. Nat. Hum. Behav. 2, 6–10 (2018). https://imai.fas.harvard.edu/research/files/significance.pdf

Amrhein, V. & Greenland, S. Remove, rather than redefine, statistical significance. Nat. Hum. Behav. 2, 4 (2018).  https://www.researchgate.net/publication/320021624_Remove_rather_than_redefine_statistical_significance


Der Klassiker:

Ioannidis, J. P. A. Why most published research findings are false. PLoS Med. 2, 0696–0701 (2005). https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124

Und Ioannidis‘ Kommentar zur aktuellen statistical Diskussion

Ioannidis, J. P. A. Retiring significance would give bias a free pass. Nature 567, 461–461 (2019). https://www.nature.com/articles/d41586-019-00969-2


Der tote Lachs im Kernspin:

Winners of the Ig® Nobel Prize. Improbable research Available at: https://www.improbable.com/ig/winners/#ig2012. (Accessed: 17th July 2019)

Bennett, C. M., Baird, A. a, Miller, M. B. & Wolford, G. L. Neural Correlates of Interspecies Perspective Taking in the Post-Mortem Atlantic Salmon: An Argument For Proper Multiple Comparisons Correction. J. Serendipitous Unexpected Results 1, 1–5 (2011). https://teenspecies.github.io/pdfs/NeuralCorrelates.pdf


Alles schon mal dagewesen:

Nickerson, R. S. Null hypothesis significance testing: A review of an old and continuing controversy. Psychol. Methods 5, 241–301 (2000). https://pdfs.semanticscholar.org/8c5e/0e6f85b9dc15ecf23d43a49404925c4c41bf.pdf


Die Empfehlungen der Statistiker:

Wasserstein, R. L., Schirm, A. L. & Lazar, N. A. Moving to a World Beyond ‘p<0.05’. Am. Stat. 73, 1–19 (2019). https://www.tandfonline.com/doi/full/10.1080/00031305.2019.1583913


Einsichten eines Wissenschaftsnarren (22):

Elon Musk’s Neurolink Präsentation https://www.youtube.com/watch?v=lA77zsJ31nA

Elon Musk. An integrated brain machine interface platform with thousands of channels. BioRxiv 2019 doi: https://doi.org/10.1101/703801

Ari N. Schulman. Why Minds Are Not Like Computers  https://www.thenewatlantis.com/publications/why-minds-are-not-like-computers

Ed Yong. The Human Brain Project Hasn’t Lived Up to Its Promise https://www.theatlantic.com/science/archive/2019/07/ten-years-human-brain-project-simulation-markram-ted-talk/594493/

Robert Epstein. The empty brain https://aeon.co/essays/your-brain-does-not-process-information-and-it-is-not-a-computer


Einsichten eines Wissenschaftsnarren (21):

Vrselja et al. https://www.nature.com/articles/s41586-019-1099-1;  feature https://www.nature.com/articles/d41586-019-01216-4

KA Hossmann and K Sato http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=4908037 showed in 1970 (quote 19 of the Nature paper!) that cat brains recover an EEG and evoked potentials after up to 1 hour complete arrest of blood circulation. This article was followed by an exchange of letters on ‘Criteria of brain death’, and Hossmann concluded :‘ This suggests that even prolonged electrocerebral silence does not prove the irreversible loss of neuronal function’ https://science.sciencemag.org/content/sci/170/3961/1000.1.full.pdf.

Circulatory arrests of up to 20 minutes are documented (silent EEG!) in which patients recovered after resuscitation, possibly with slight neuropsychological deficits (mostly memory deficits, see below, as a result ofdelayed neuronal cell death, this was shown by neuropathologists in the 80s and 90s, see Petito et al. https://www.ncbi.nlm.nih.gov/pubmed/3614648).

A recent expample of an isolated perfused brain preparation: Breschi et al. https://doi.org/10.1111/j.1528-1167.2011.03356.x.

‘Delayed neuronal vulnerability’ (and by older neuropathologists ‘maturation phenomenon’) was described by Ito, Klatzo and others https://www.ncbi.nlm.nih.gov/pubmed/1180003.


Einsichten eines Wissenschaftsnarren (20):

Inspiriert wurde mein Beitrag von Anne Scheels sehr gutem Blogpost ‚Why we should love null results‘ http://www.the100.ci/2017/06/01/why-we-should-love-null-results/

Hilfestellung beim Publizieren von NULL-Resultaten finden Sie bei FIDDLE – File Drawer Data Liberation Effort. Where and how to publish null / neutral results? http://s-quest.bihealth.org/fiddle/

Leider nur an Charité und Max Delbrück Center: Der 1.000 € QUEST-Preis für NULL-Ergebnisse und Replikationsstudien. Veröffentlichen Sie Ihr NULL-Ergebnis – Kämpfen Sie gegen das negative Publikations-Vorurteil an! Veröffentlichen Sie Ihre Replikationsstudien – Kämpfen Sie gegen die Replikationskrise an! https://www.bihealth.org/de/forschung/quest-center/initiativen/

DORA Blog zur  Charité Rekrutierungspraxis für Professuren https://sfdora.org/2018/07/06/simple-questions-big-insights-charite-uses-bio-sketch-questions-to-recruit-faculty/

Marcus Munafò, Jo Neill. Null is beautiful: On the importance of publishing null results. Journal of Psychopharmacology: 2016, 30 page(s): 585-585 https://journals.sagepub.com/doi/full/10.1177/0269881116638813

Chris A. Mack. In Praise of the Null Result.  J. of Micro/Nanolithography, MEMS, and MOEMS, 13(3), 030101 (2014). https://www.spiedigitallibrary.org/journals/Journal-of-MicroNanolithography-MEMS-and-MOEMS/volume-13/issue-03/030101/In-Praise-of-the-Null-Result/10.1117/1.JMM.13.3.030101.full?SSO=1

Ulrich Dirnagl ‚Wie originell sind eigentlich Ihre Hypothesen‘ Laborjournal 4/2017, p.24-25 https://dirnagl.files.wordpress.com/2018/02/einsichten-eines-wissenschaftsnarren-1-lj_17_04.pdf


Einsichten eines Wissenschaftsnarren (19):

Volkswagen Experiment! 

Dorothy Bishop’s blog regarding VW-Funding Lottery 


More literature on research funding lotteries:

Avin S. Policy Considerations for Random Allocation of Research Funds.  RT. A Journal on Research Policy & Evaluation 1 (2018) Submitted on 23 June 2017, accepted on 21 September 2017, published on 1 March 2018

Avin S. Funding Science by Lottery. 2015 In: Mäki U., Votsis I., Ruphy S., Schurz G. (eds) Recent Developments in the Philosophy of Science: EPSA13 Helsinki. European Studies in Philosophy of Science, vol 1. Springer, Cham.

Avin S. Centralised Funding and Epistemic Exploration. Penultimate draft. Final draft forthcoming in The British Journal for the Philosophy of Science (BJPS).

Egger M. Random selection for science funding: not such a crazy idea. 2018. Horizons 

Fang FC, Casadevall A. 2016. Research funding: the case for a modified lottery. mBio 7(2):e00422-16.

Firpo T,  Smith L.  A random approach to innovation. 2018. NESTA  

Klaus B, del Alamo D. Talent Identification at the limits of Peer Review: an analysis of the EMBO Postdoctoral Fellowships Selection Process BioRxiv. 2018


Einsichten eines Wissenschaftsnarren (18):

Link zur BMBF Ausschreibung: Richtlinie zur Förderung von konfirmatorischen präklinischen Studien – Qualität in der Gesundheitsforschung – Bundesanzeiger vom: 27.12.2018 Abgabetermin: 28.03.2019 Die Texte sowie weitere Unterlagen und Links finden Sie hier: https://www.gesundheitsforschung-bmbf.de/de/8344.php

Munafò MR, Davey Smith G. Robust research needs many lines of evidence. Nature. 2018 Jan 25;553(7689):399-401.


Einsichten eines Wissenschaftsnarren (17):

Carmen M. Reinhart & Kenneth S. Rogoff, 2010. “Growth in a Time of Debt,” American Economic Review, American Economic Association, vol. 100(2), pages 573-78 https://www.nber.org/papers/w15639

Dirnagl U, Przesdzing I, Kurreck C, Major S. A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine.PLoS Biol. 2016 Dec 1;14(12):e2000705. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2000705

Dirnagl U, Bernard R. Errors and error management in biomedical research. In: How Could This Happen? Managing Errors in Organizations, Palgrave Macmillan, Cham (978-3-319-76403-0). https://zenodo.org/record/1406922#.XC5QQVxKjZt

Methodischer Leitfaden Morbiditäts- und Mortalitätskonferenzen (M & MK) der Bundesärztekammer https://www.bundesaerztekammer.de/fileadmin/user_upload/downloads/pdf-Ordner/QS/M_Mk.pdf

Bsp. aus retractionwatch.com aus der Kategorie „doing the right thing“ , also einer ‚gut gemachten‘ Retraktion wegen honest error https://retractionwatch.com/2013/10/10/ronald-science/


Einsichten eines Wissenschaftsnarren (16):

Halkjær SI, Christensen AH, Lo BZS, Browne PD, Günther S, Hansen LH, Petersen AM. Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study. Gut. 2018 Jul 6. pii: gutjnl-2018-316434. doi: 10.1136/gutjnl-2018-316434.

Overselling the microbiome in The Tree of Life. Blog of Jonathan A. Eisen, Professor at U.C. Davis. https://phylogenomics.blogspot.com/search/label/overselling%20the%20microbiome

Guyenet S. Microbiota and obesity: Is it all hype? http://www.stephanguyenet.com/microbiota-and-obesity-is-it-all-hype/

Valencia PM, Richard M, Brock J, Boglioli E. The human microbiome: opportunity or hype? Nat Rev Drug Discov. 2017 Dec;16(12):823-824. doi: 10.1038/nrd.2017.154. Epub 2017 Sep 15.

100 Years Later: The Lone German Soldier Whose Poop Fights on https://ubiome.com/blog/post/100-years-later-lone-german-soldier-whose-poop-fights/


Einsichten eines Wissenschaftsnarren (15):

Robin Hanson (1995) Could gambling save science? Encouraging an honest consensus, Social Epistemology: A Journal of Knowledge, Culture and Policy, 9:1, 3-33, DOI: 10.1080/02691729508578768 http://dx.doi.org/10.1080/02691729508578768

Michael Thicke (2017) Prediction Markets for Science: Is the Cure Worse than the Disease?, Social Epistemology, 31:5, 451-467, DOI: 10.1080/02691728.2017.1346720  https://doi.org/10.1080/02691728.2017.1346720

Dreber A, Pfeiffer T, Almenberg J, Isaksson S, Wilson B, Chen Y, Nosek BA, Johannesson M. (2015) Using prediction markets to estimate the reproducibility of scientific research.  Proc Natl Acad Sci U S A. Dec 15;112(50):15343-7. doi: 10.1073/pnas.1516179112. Epub 2015 Nov 9

Munafo MR, Pfeiffer T, Altmejd A, Heikensten E, Almenberg J, Bird A, Chen Y, Wilson B, Johannesson M, Dreber A. (2015) Using prediction markets to forecast research evaluations. R Soc Open Sci. Oct 28;2(10):150287. doi: 10.1098/rsos.150287. eCollection 2015 Oct. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632515/

Colin F. Camerer, Anna Dreber, Felix Holzmeister, Teck-Hua Ho, Jürgen Huber, Magnus Johannesson, Michael Kirchler, Gideon Nave, Brian A. Nosek, Thomas Pfeiffer, Adam Altmejd, Nick Buttrick, Taizan Chan, Yiling Chen, Eskil Forsell, Anup Gampa, Emma Heikensten, Lily Hummer, Taisuke Imai, Siri Isaksson, Dylan Manfredi, Julia Rose, Eric-Jan Wagenmakers & Hang Wu. (2018) Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015. Nature Human Behaviourvolume 2, pages 637–644  https://www.nature.com/articles/s41562-018-0399-z


Übrigens ähnelt der vom Wissenschaftsnarren zitierte Artikel von Robin Hanson, in dem er Prediction markets für die Konsensusfindung in der Forschung vorschlägt, in seiner Anlage, Radikaliät und Innovation dem des mysteriösen Blockchain-Erfinder Satoshi Nakamoto. Dieser hatte in seinem legendären Artikel ausgehend von einer Kritik gängiger Zahlungsysteme ein digitales Währungsprinzip vorgeschlagen, welches nicht nur Spekulanten angelockt hat, sondern mittlerweile in einer Vielzahl von Anwendungen eingesetzt wird, bei denen es um distribuierte Buchführung geht.

Nakamoto, S (2012) Bitcoin: A Peer-to-Peer Electronic Cash System. http://article.gmane.org/gmane.comp.encryption.general/12588/


Einsichten eines Wissenschaftsnarren (14):

Yarborough M, Bredenoord A, D’Abramo F, Joyce NC, Kimmelman J, Ogbogu U, Sena E, Strech D, Dirnagl U. The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials. PLoS Biol. 2018 Jun 6;16(6):e2006343. doi: 10.1371/journal.pbio.2006343.

.Yarborough M, Dirnagl U. Preclinical research: Meet patients to sharpen up research. Nature. 2017 Nov 16;551(7680):300. doi: 10.1038/d41586-017-06024-2.

New York Times Published: April 6, 2009, Radiologist Adds a Human Touch. https://archive.nytimes.com/www.nytimes.com/2009/04/07/health/07pati.html

Turner Y, Hadas-Halpern I. The effects of including a patient’s photograph to the radiographic examination. Presented at: Radiological Society of North America Scientific Assembly and Annual Meeting; Oak Brook, Illinois; 2008.



Ryan J, Khanda GE, Hibbert R, Duigenan S, Tunis A, Fasih N1, MacDonald B, El-Khoudary M, Kielar A, McInnes M, Virmani V, Ramamurthy N, Kolenko N, Sheikh A. Is a picture worth a thousand words? The effect of viewing patient photographs on radiologist interpretation of CT studies. J Am Coll Radiol. 2015 Jan;12(1):104-7. doi: 10.1016/j.jacr.2014.09.028.


Einsichten eines Wissenschaftsnarren (13):

Dirnagl U. Räuberische Fachverlage: Veröffentlichen um jeden Preis – Gastbeitrag im Tagesspiegel, 21.7.2018

Leininger A. Storm in a teacup: predatory journals are irrelevant http://elephantinthelab.org/storm-in-a-teacup-predatory-journals-are-irrelevant/

Nellen W. Der „Fake Science-Skandal“ – eine Meinung! https://www.laborjournal.de/blog/?p=9840

Pössel M. Abzock-Zeitschriften, Datenauswertung Teil 1: Methoden, Ländervergleich, Gesamtzahl. https://scilogs.spektrum.de/relativ-einfach/abzock-zeitschriften-den-daten-auf-der-spur/

Björn Brembs‘ kritische Analyse der gegenwärtigen OA Initiativen: http://bjoern.brembs.net/2017/03/please-address-these-concerns-before-we-can-accept-your-oa-proposal/

Björn Brembs warnt, dass der Königsweg des OA (‚Goldener OA‘) mehr Probleme verursachen könnte, als er löst: http://bjoern.brembs.net/2016/04/how-gold-open-access-may-make-things-worse/

SCI-HUB: legal – iIlegal – scheissegal. Über 40 Millionen Artikel zum Download.  Radikal illegaler Open Access.  https://dirnagl.com/?s=sci-hub


Einsichten eines Wissenschaftsnarren (12):

Norris D, Dirnagl U, Zigmond MJ, Thompson-Peer K, Chow TT. Health tips for research groups. Nature. 2018 May;557(7705):302-304. doi: 10.1038/d41586-018-05146-5


Einsichten eines Wissenschaftsnarren (11):

Fanelli D. Is science really facing a reproducibility crisis, and do we need it to? Proc Natl Acad Sci U S A. 2018;115:2628-2631

Fisher, R. A. (1935). The design of experiments. Oliver & Boyd Oxford

Kuhn TS. (1962) The structure of scientific revolutions. University of Chicago Press.

Popper, K. (1935) Logik der Forschung. Springer Berlin


Einsichten eines Wissenschaftsnarren (10):

Gelman A and Loken E (2013) The garden of forking paths: Why multiple comparisons can be a problem, even when there is no  “fishing expedition” or “p-hacking” and the research hypothesis was posited ahead of time. http://www.stat.columbia.edu/~gelman/research/unpublished/p_hacking.pdf


Gelman A and Loken E (2014) The statistical crisis in science. American Scientist 102:460-465


de Groot AD (1956) The meaning of “significance” for different types of research [translated and annotated by Eric-Jan Wagenmakers, Denny Borsboom, Josine Verhagen, Rogier Kievit, Marjan Bakker, Angelique Cramer, Dora Matzke, Don Mellenbergh, and Han L. J. van der Maas]. Acta Psychol (Amst). 2014 May;148:188-94. doi: 10.1016/j.actpsy.2014.02.001. Epub 2014 Mar 3. http://www.sciencedirect.com/science/article/pii/S0001691814000304?via%3Dihub


Yogi Berra: When you come to a fork in the road, take it! https://quoteinvestigator.com/2013/07/25/fork-road/



Einsichten eines Wissenschaftsnarren (9):

Researchers were disappointed when a clinical trial of a new tuberculosis vaccine failed to show benefit, but should it have gone ahead when animal studies had already raised doubts and what does it mean for future research? Deborah Cohen investigates:

Cohen D. Oxford vaccine study highlights pick and mix approach to preclinical research. BMJ. 2018 Jan 10;360:j5845. http://www.bmj.com/content/360/bmj.j5845.long


We must review how we use animal data to underpin clinical trials in humans:

Macleod M. Learning lessons from MVA85A, a failed booster vaccine for BCG. BMJ. 2018 Jan 10;360:k66. http://www.bmj.com/content/360/bmj.k66.long


Responsible bodies should demand high quality reporting and systematic reviews of animal studies:

Ritskes-Hoitinga M, Wever K.Improving the conduct, reporting, and appraisal of animal research. BMJ. 2018 Jan 10;360:j4935. http://www.bmj.com/content/360/bmj.j4935.long


A systematic review of the animal data does not provide evidence to support efficacy of MVA85A as a BCG booster:

Kashangura R, Sena ES, Young T, Garner P. Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review. Int J Epidemiol. 2015 Dec;44(6):1970-81.  https://academic.oup.com/ije/article/44/6/1970/2572503


Einsichten eines Wissenschaftsnarren (8):

As always, David Colquhoun brilliantly summarizes the issue in his blog DC’s Improbable Science:

Colquhoun D. Placebo effects are weak: regression to the mean is the main reason ineffective treatments appear to work. http://www.dcscience.net/2015/12/11/placebo-effects-are-weak-regression-to-the-mean-is-the-main-reason-ineffective-treatments-appear-to-work/


Highly recommended. Stephen Senn tackles the issue with a historical excursion, and a bit more serious statistics. Contains references to full statistical treatments of regression to the mean:

Senn S (2011)  Francis Galton and regression to the mean. Significance 8:124-126 http://onlinelibrary.wiley.com/doi/10.1111/j.1740-9713.2011.00509.x/full


When the first large Cochrane review was published, concluding that there is little evidence to support the existence of the placebo effect, the New England Journal ran this very readable editorial:

Bailar JC (2001) The Powerful Placebo and the Wizard of Oz. N Engl J Med 2001; 344:1630-1632 http://www.nejm.org/doi/full/10.1056/NEJM200105243442111


Most recent Cochrane review on placebo interventions:

Hróbjartsson A, Gøtzsche PC (2010)  Placebo interventions for all clinical conditions. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD003974. doi: 10.1002/14651858.CD003974.pub3


This narrative review present the classic view on placebo effects. The authors use only one citation (to another narrative review by the same authors) to claim the existence of the placebo effect:

 ‘ Moreover, recent clinical research into placebo effects has provided compelling evidence that these effects are genuine biopsychosocial phenomena that represent more than simply spontaneous remission, normal symptom fluctuations, and regression to the mean. “

It would have been nice to see reference to evidence from original studies or systematic reviews.

Kaptchuk TJ, Miller FG (2015) Placebo Effects in Medicine. N Engl J Med 2015; 373:8-9July 2, 2015 http://www.nejm.org/doi/full/10.1056/NEJMp1504023#t=article



Einsichten eines Wissenschaftsnarren (7):

OPERA collaboration, T. Adam et al., Measurement of the neutrino velocity with the OPERA detector in the CNGS beam, arXiv:1109.4897v2.

Daniel J. Benjamin et al. Redefine statistical significance. Nat Hum Behav Published 1: 0189. DOI: 10.1038/s41562-017-0189-z

Valentin Amrhein, Sander Greenland. Remove, rather than redefine, statistical significance Nat human behaviour Nature Human Behaviour. 1: 0224. doi:10.1038/s41562-017-0224-0


Einsichten eines Wissenschaftsnarren (6):

Yong, E. The Absurdity of the Nobel Prizes in Science – The Atlantic

Knorr-Cetina, Karin D.: Epistemic Cultures – How the Sciences Make Knowledge. Cambridge: Harvard University Press, 1999


Einsichten eines Wissenschaftsnarren (5): 

Kimmelman J, Mogil JS, Dirnagl U. Distinguishing between exploratory and confirmatory preclinical research will improve translation. PLoS Biol. 2014 May 20;12(5):e1001863. doi: 10.1371/journal.pbio.1001863. eCollection 2014 May. http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001863

Mogil JS, Macleod MR. No publication without confirmation. Nature. 2017 Feb 22;542(7642):409-11. doi: 10.1038/542409a. PMID: 28230138; https://www.nature.com/news/no-publication-without-confirmation-1.21509

Bazerman,  Shaping Written Knowledge: The Genre and Activity of the Experimental Article in Science: Genre and Activity of Experimental Article in Science, University of Wisconsin Press, 1988. https://wac.colostate.edu/books/bazerman_shaping/shaping.pdf


Einsichten eines Wissenschaftsnarren (4): Exzellenztheater: Zeit für einen Wechsel im Spielplan?

Der Titel sagt eigentlich alles: Fang, Ferric C., Anthony Bowen, and Arturo Casadevall. 2016. “NIH Peer Review Percentile Scores Are Poorly Predictive of Grant Productivity.” eLife 5 (February). doi: 10.7554/eLife.13323 . https://elifesciences.org/articles/13323

Ein Klassiker der Wissenschaftsgeschichte und -theorie. Nach TS Kuhn schreitet die Evolution von Wissen fort durch „normal science“, unterbrochen durch ‚Paradigmenwechsel‘ (da kommt auch der Begriff her): Kuhn TS. The structure of scientific revolutions. University of Chicago Press. 1962 (50th anniversary edition 2012)

Richard Münch’s 500 seitiger Frontalangriff auf Exzellenzinitiative, DFG, usw. Nichts für schwache Nerven: Münch, R. Die akademische Elite: Zur sozialen Konstruktion wissenschaftlicher Exzellenz (edition suhrkamp 2510). Frankfurt am Main 2007

Eine fundierte Abrechnung mit dem Begriff ‚Excellence‘, vor dem Hintergrund der englischen REF: Stilgoe, Jack. 2014. “Against Excellence.” The Guardian , December 19. https://www.theguardian.com/science/political-science/2014/dec/19/against-excellence


Einsichten eines Wissenschaftsnarren (3): Werden Sie Forschungsförderer!

Diese beiden Arbeiten beschreiben das System in allen Einzelheiten:

Bollen J, Crandall D, Junk D, Ding Y, Börner K. From funding agencies to scientific agency: Collective allocation of science funding as an alternative to peer review. EMBO Rep. 2014 Feb;15(2):131-3. http://embor.embopress.org/content/15/2/131

Diese Arbeit ‘erprobt’ das System zudem in einer Simulation: Bollen, J., Crandall, D., Junk, D. et al. An efficient system to fund science: from proposal review to peer-to-peer distributions Scientometrics (2017) 110: 521. doi:10.1007/s11192-016-2110-3  https://link.springer.com/article/10.1007%2Fs11192-016-2110-3

Das schreibt Retraction Watch zum peer funding: https://www.evernote.com/shard/s21/nl/2303872/2592c704-d95b-41b6-aba9-00b4565aeab6/ ..

… und dies Science: http://www.sciencemag.org/news/2017/04/new-system-scientists-never-have-write-grant-application-again


Und dies kam eben rein (19.9.2017)

How much would each researcher receive if competitive government research funding were distributed equally among researchers?

‘According to our results, researchers could, on average, maintain current PhD student and Postdoc employment levels, and still have at their disposal a moderate (the U.K.) to considerable (the Netherlands, U.S.) budget for travel and equipment. This suggests that the worry that egalitarian sharing leads to unacceptable dilution of resources is unjustified. Indeed, our results strongly suggest that there is room for far more egalitarian distribution of funds than happens in the highly competitive funding schemes so prevalent today.’

PLoS ONE 12(9): e0183967. https://doi.org/10.1371/journal.pone.0183967


Weitere interessante Arbeiten:

NIH Funding für den Mainstream, innovative Arbeiten werden nicht oder woanders gefördert:

Nicholson JM, Ioannidis JP. Research grants: Conform and be funded. Nature. 2012 Dec 6;492(7427):34-6. https://www.nature.com/nature/journal/v492/n7427/full/492034a.html

‘Peer review of grant proposals, far from being a reasonable way of ensuring quality by the allocation of funds, is a near disaster.’: Horrobin DF. Peer review of grant applications: a harbinger for mediocrity in clinical research? Lancet. 1996 Nov 9;348(9037):1293-5 http://www.sciencedirect.com/science/article/pii/S0140673696080294

Nicholson, J. M. (2012), Collegiality and careerism trump critical questions and bold new ideas: A student’s perspective and solution. Bioessays, 34: 448–450. doi:10.1002/bies.201200001 http://onlinelibrary.wiley.com/doi/10.1002/bies.201200001/epdf

Von historischem Interesse: Ein Faksimile von Otto Warburgs ‘Forschungsantrag’ bei der Notgemeinschaft der Deutschen Wissenschaft (1921). Das waren noch Zeiten! https://dirnagl.com/?s=warburg



Einsichten eines Wissenschaftsnarren (2): Zu Risiken und Nebenwirkungen fragen Sie Ihren Bibliothekar

Ein wunderbarer Vergleich zwischen der ineffizienten Weise, in der wir heute wissenschaftliche Resultate veröffentlichen, und was alles möglich wäre, wenn wir die Möglichkeiten es besser zu machen, nutzen würden (von Romain Brette) : A vision of the post-journal world. http://romainbrette.fr/a-vision-of-the-post-journal-world/

Gleich nochmal Romain Brette, mit einfachen Schritten wie in diese wunderbare Welt kommen: http://romainbrette.fr/my-new-year-resolution-to-help-move-science-to-the-post-journal-world/

Björn Brembs  gibt Tips was man tun kann, wenn man den Zugang zu Journalen verloren hat. Weil die Subskription gekündigt wurde, oder man auf der falschen Seite des Paywalls sitzt. Alles halb so wild…: http://bjoern.brembs.net/2016/12/so-your-institute-went-cold-turkey-on-publisher-x-what-now/

Björn Brembs rät, alle Journalsubskriptionen zu kündigen: http://bjoern.brembs.net/2016/05/why-havent-we-already-canceled-all-subscriptions/

Björn Brembs‘ kritische Analyse der gegenwärtigen OA Initiativen: http://bjoern.brembs.net/2017/03/please-address-these-concerns-before-we-can-accept-your-oa-proposal/

Björn Brembs warnt, dass der Königsweg des OA (‚Goldener OA‘) mehr Probleme verursachen könnte, als er löst: http://bjoern.brembs.net/2016/04/how-gold-open-access-may-make-things-worse/

Und jetzt auch das noch: Björn Brembs, Deutschland’s prominentester Open Science Aktivist kündigt frustiert seinen Rückzug an: http://bjoern.brembs.net/2017/02/open-science-too-much-talk-too-little-action/

SCI-HUB: legal – iIlegal – scheissegal. Über 40 Millionen Artikel zum Download.  Radikal illegaler Open Access.  https://dirnagl.com/?s=sci-hub

Oder nicht ganz so umfänglich, dafür legal, und sehr bequem mit Browser Extention: ‚Skip the paywall‘  Get full-text of research papers as you browse, using Unpaywall’s index of ten million legal, open-access articles.  http://unpaywall.org/

The Costs of Flipping our Dollars to Gold. Interview about the Pay It Forward report. The first comprehensive analysis of how a decisive push to Gold OA would impact the cost of publication for major North American research institutions. https://scholarlykitchen.sspnet.org/2016/08/24/the-costs-of-flipping-our-dollars-to-gold/

Elsevierleaks: Leaked Elsevier contract reveals pushback: http://scienceguide.nl/201703/leaked-elsevier-contract-reveals-pushback.aspx

Thomson-Reuters verkauft den Impact Factor an Venture Kapitalisten: http://www.marketwatch.com/story/thomson-reuters-announces-definitive-agreement-to-sell-its-intellectual-property-science-business-to-onex-and-baring-asia-for-355-billion-2016-07-11

PIPredictor – Predict your probability to become a Principal Investigator (PI) http://pipredictor.com

Berliner Erklärung zu Open Access. 60% bis 2020!: https://openaccess.mpg.de/Berliner-Erklaerung

Das BMBF zu OA: https://www.bmbf.de/de/open-access-das-urheberrecht-muss-der-wissenschaft-dienen-846.html

Missbrauch der Marktmacht. TAZ Artikel zum DEAL Konsortium und Elsevier: http://www.taz.de/!5370972/


Auch lesenswert:

Brembs BButton KMunafò M. Deep impact: unintended consequences of journal rank. Front Hum Neurosci. 2013 Jun 24;7:291. http://journal.frontiersin.org/article/10.3389/fnhum.2013.00291/full

Kriegeskorte N, Walther A, Deca D. An emerging consensus for open evaluation: 18 visions for the future of scientific publishing. Front Comput Neurosci. 2012 Nov 15;6:94. http://journal.frontiersin.org/article/10.3389/fncom.2012.00094/full

Khan R, Goodman L, Mittelman D. Dragging scientific publishing into the 21st century. Genome Biol. 2014 Dec 11;15(12):556. https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0556-2



Einsichten eines Wissenschaftsnarren (1): Wie originell sind eigentlich Ihre wissenschaftlichen Hypothesen?

Baker M. 1,500 scientists lift the lid on reproducibility. Nature. 2016 May 26;533(7604):452-4. doi: 10.1038/533452a

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